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The database of clinical evidence informing recommendations on Span.

Diabetes

Genetic variants for personalised management of very low carbohydrate ketogenic diet

Lucia Aronica, Jeff Volek, Angela Poff, Dominic P D'agostino
BMJ Nutrition, Prevention & Health
2020
Metabolic Syndrome

Effects of Intermittent Fasting on Health, Aging, and Disease

Rafael de Cabo, Ph.D., and Mark P. Mattson, Ph.D
The New England Journal of Medicine
2019

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J. Mack, Esra Guen, Stefano Di Biase, Pinchas Cohen, Todd E. Morgan, Tanya Dorff, Kurt Hong, Andreas Michalsen, Alessandro Laviano, Valter D. Longo
Science Translational Medicine
2017

Personalized Nutrition by Prediction of Glycemic Responses

David Zeevi, Tal Korem, Niv Zmora, David Israeli, Daphna Rothschild, Adina Weinberger, Orly Ben-Yacov, Dar Lador, Tali Avnit-Sagi, Maya Lotan-Pompan, Jotham Suez, Jemal Ali Mahdi, Elad Matot, Gal Malka, Noa Kosower, Michal Rein, Gili Zilberman-Schapira, Lenka Dohnalova, Meirav Pevsner-Fischer, Rony Bikovsky, Zamir Halpern, Eran Elinav, and Eran Segal
Cell
2015
Metabolic Syndrome

Akkermansia Muciniphila and Improved Metabolic Health During a Dietary Intervention in Obesity: Relationship With Gut Microbiome Richness and Ecology

Maria Carlota Dao, Amandine Everard , Judith Aron-Wisnewsky, Nataliya Sokolovska, Edi Prifti, Eric O Verger, Brandon D Kayser, Florence Levenez, Julien Chilloux, Lesley Hoyles, MICRO-Obes Consortium; Marc-Emmanuel Dumas, Salwa W Rizkalla, Joel Doré, Patrice D Cani , Karine Clément
Gut
2015
Metabolic Syndrome

Fecal microbiota transplantation improves metabolic syndrome parameters: systematic review with meta-analysis based on randomized clinical trials

Igor M.Proençaa, Jessica R.Allegrettib, Wanderley M.Bernardoa, Diogo T.H.de Mouraa, Alberto M.Ponte Netoa, Carolina O.Matsubayashia, Marcelo M.Flora, Ana P.S.T.Kotindaa, Eduardo G.H.de Mouraa
Nutrition Research
2020
Metabolic Syndrome

Do Lower-Carbohydrate Diets Increase Total Energy Expenditure? An Updated and Reanalyzed Meta-Analysis of 29 Controlled-Feeding Studies

David S Ludwig, Stephanie L Dickinson, Beate Henschel, Cara B Ebbeling, David B Allison
The Journal of Nutrition
2020
PCOS

Effects of a Ketogenic Diet in Overweight Women With Polycystic Ovary Syndrome

Antonio Paoli, Laura Mancin, Maria Cristina Giacona, Antonino Bianco and Massimiliano Caprio
Journal of Translational Medicine
2020
Diabetes

Low-Carbohydrate Diets in the Management of Obesity and Type 2 Diabetes: A Review from Clinicians Using the Approach in Practice

Tara Kelly, David Unwin, Francis Finucane
International Journal of Environmental Research and Public Health
2020
Metabolic Syndrome

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

Panu K. Luukkonen, Sylvie Dufour, Kun Lyu, Xian-Man Zhang, Antti Hakkarainen, Tiina E. Lehtimäki, Gary W. Cline, Kitt Falk Petersen, Gerald I. Shulman, and Hannele Yki-Järvinen
PNAS
2020
Metabolic Syndrome

Effects of weight loss during a very low carbohydrate diet on specific adipose tissue depots and insulin sensitivity in older adults with obesity

Amy M Goss, Barbara Gower, Taraneh Soleymani, Mariah Stewart, May Pendergrass, Mark Lockhart, Olivia Krantz, Shima Dowla, Nikki Bush, Valene Garr Barry & Kevin R. Fontaine
Nutrition & Metabolism
2020
Metabolic Syndrome

Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

Michael J. Wilkinson, Emily N.C. Manoogian, Adena Zadourian, Hannah Lo, Savannah Fakhouri, Azarin Shoghi, Xinran Wang, Jason G. Fleischer, Saket Navlakha, Satchidananda Panda, Pam R. Taub
Cell Metabolism
2019
Metabolic Syndrome

Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 Diabetes Consuming a Three-Meal Diet: A Randomized Clinical Trial

Daniela Jakubowicz, Zohar Landau, Shani Tsameret, Julio Wainstein, Itamar Raz, Bo Ahren, Nava Chapnik, Maayan Barnea, Tali Ganz, Miriam Menaged, Naomi Mor, Yosefa Bar-Dayan, and Oren Froy
Diabetes Care
2019
Metabolic Syndrome

Effect of breakfast on weight and energy intake: systematic review and meta-analysis of randomised controlled trials

Katherine Sievert, Sultana Monira Hussain, Matthew J Page, Yuanyuan Wang, Harrison J Hughes, Mary Malek, Flavia M Cicuttini
British Medical Journal
2019
Metabolic Syndrome

The Effectiveness of Intermittent Fasting to Reduce Body Mass Index and Glucose Metabolism: A Systematic Review and Meta-Analysis

Yongin Cho, Namki Hong, Kyung-won Kim, Sung joon Cho, Minyoung Lee, Yeon-hee Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, and Byung-Wan Lee
The Journal of Clinical Medicine
2019
PCOS

A New Approach to Polycystic Ovary Syndrome: The Gut Microbiota

Gamze Yurtdaş & Yasemin Akdevelioğlu
Journal of the American College of Nutrition
2019
PCOS

The Triad Of PCOS, Infertility And Metformin

Ayesha Khan, Nasim Karim, Jahan Ara Ainuddin
JBUMDC
2019
PCOS

The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials

Xiaoshuai Zhang , Yang Zheng , Yanan Guo and Zhiwen Lai
International Journal of Endocrinology
2019
Diabetes

Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report

Alison B. Evert, Michelle Dennison, Christopher D. Gardner, W. Timothy Garvey, Ka Hei Karen Lau, Janice MacLeod, Joanna Mitri, Raquel F. Pereira, Kelly Rawlings, Shamera Robinson, Laura Saslow, Sacha Uelmen, Patricia B. Urbanski, William S. Yancy
Diabetes Care
2019
Diabetes

Improving the Scientific Rigour of Nutritional Recommendations for Adults With Type 2 Diabetes: A Comprehensive Review of the American Diabetes Association Guideline-Recommended Eating Patterns

Sarah J Hallberg, Nancy E Dockter, Jake A Kushner , Shaminie J Athinarayanan
Diabetes Obesity and Metabolism
2019
Diabetes

Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss Copy

Parker N. Hyde, Teryn N. Sapper, Christopher D. Crabtree, Richard A. LaFountain, Madison L. Bowling, Alex Buga, Brandon Fell, Fionn T. McSwiney, Ryan M. Dickerson, Vincent J. Miller, Debbie Scandling, Orlando P. Simonetti, Stephen D. Phinney, William J. Kraemer, Sarah A. King, Ronald M. Krauss, and Jeff S. Volek
JCI Insight
2019
Diabetes

A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes

Mads J. Skytte, Amirsalar Samkani, Amy D. Petersen, Mads N. Thomsen, Arne Astrup, Elizaveta Chabanova, Jan Frystyk, Jens J. Holst, Henrik S. Thomsen, Sten Madsbad, Thomas M. Larsen, Steen B. Haugaard & Thure Krarup
Diabetologia
2019
Diabetes

Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-year Non-randomized Clinical Trial

Shaminie J. Athinarayanan, Rebecca N. Adams, Sarah J. Hallberg, Amy L. McKenzie, Nasir H. Bhanpuri, Wayne W. Campbell, Jeff S. Volek, Stephen D. Phinney, James P. McCarter
Frontiers in Endocrinology
2019
Metabolic Syndrome

Effects of a Carbohydrate-Restricted Diet on Hepatic Lipid Content in Adolescents with Nonalcoholic Fatty Liver Disease

Amy M. Goss, Shima Dowla, Ambika P. Ashraf, Mark Bolding, Shannon A. Morrison and Barbara Gower
Diabetes
2019
Metabolic Syndrome

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

Jane M. Natividad, Allison Agus, Julien Planchais, ..., Ramnik J. Xavier, Henri Duboc, Harry Sokol
Cell Metabolism
2018
Diabetes

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

Elizabeth F. Sutton Robbie Beyl Kate S. Early William T. Cefalu Eric Ravussin Courtney M. Peterson
Cell Metabolism
2018
Metabolic Syndrome

Intermittent fasting interventions for treatment of overweight and obesity in adults a systematic review and meta-analysis

Leanne Harris, Sharon Hamilton, Liane Azevedo, Joan Olajide, Caroline De Brún, Gillian Waller, Vicki Whittaker, Tracey Sharp, Mike Lean, Catherine Hankey, Louisa Ells
JBI Synthesis
2018
Metabolic Syndrome

Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial

Cara B Ebbeling, Henry A Feldman, Gloria L Klein, Julia M W Wong, Lisa Bielak, Sarah K Steltz, Patricia K Luoto, Robert R Wolfe, William W Wong and David S Ludwig
The British Medical Journal
2018
Diabetes

Carbohydrate restriction for glycaemic control in Type 2 diabetes: a systematic review and meta‐analysis

P. D. McArdle S. M. Greenfield S. K. Rilstone P. Narendran M. S. Haque P. S. Gill
Diabetic Medicine
2018
Diabetes

Effects of low-carbohydrate- compared with low-fat-diet interventions on metabolic control in people with type 2 diabetes: a systematic review including GRADE assessments

Esther J van Zuuren, Zbys Fedorowicz, Ton Kuijpers and Hanno Pijl
The American Journal of Clinical Nutrition
2018
Diabetes

Effect of dietary carbohydrate restriction on glycemic control in adults with diabetes: A systematic review and meta-analysis

Emma Sainsbury, Nathalie V.Kizirian, Stephanie R.Partridge, TimothyGill, StephenColagiuri, Alice A.Gibson
Diabetes Research and Clinical Practice
2018
Metabolic Syndrome

Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics

Mingqian He and Bingyin Shi
Cell & Bioscience
2017
Metabolic Syndrome

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting

Stephen D. Anton Keelin Moehl William T. Donahoo Krisztina Marosi Stephanie A. Lee Arch G. Mainous III Christiaan Leeuwenburgh Mark P. Mattson
Obesity
2017
Metabolic Syndrome

Metabolic Effects of Intermittent Fasting

Ruth E. Patterson and Dorothy D. Sears
Annual Review of Nutrition
2017
PCOS

Association of polycystic ovary syndrome with metabolic syndrome and gestational diabetes: Aggravated complication of pregnancy

Kui Yao, Ce Bian and Xia Zhao
Experimental and Therapeutic Medicine
2017
Diabetes

Systematic review and meta-analysis of dietary carbohydrate restriction in patients with type 2 diabetes

Ole Snorgaard, Grith M Poulsen, Henning K Andersen, Arne Astrup
BMJ Open Diabetes Research and Care
2017
Diabetes

Efficacy of Low Carbohydrate Diet for Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yan Meng, Hao Bai , Shijun Wang, Zhaoping Li , Qian Wang, Liyong Chen
Diabetes Research Clinical Practice
2017

Fasting and Caloric Restriction in Cancer Prevention and Treatment

Sebastian Brandhorst, Valter D. Longo
Springer
2016
Metabolic Syndrome

Dietary carbohydrate intake, insulin resistance and gastro‐oesophageal reflux disease: a pilot study in European‐ and African‐American obese women

S. D. Pointer J. Rickstrew J. C. Slaughter M. F. Vaezi H. J. Silver
Alimentary Pharmacology and Therapeutics
2016
PCOS

The Effect of Low Carbohydrate Diets on Fertility Hormones and Outcomes in Overweight and Obese Women: A Systematic Review

Melanie McGrice and Judi Porter
Nutrients
2016
Metabolic Syndrome

Impact of Low-Carbohydrate Diet on Body Composition: Meta-Analysis of Randomized Controlled Studies

Y Hashimoto , T Fukuda, C Oyabu, M Tanaka, M Asano, M Yamazaki, M Fuku
Obesity Reviews
2016
Metabolic Syndrome

Effects of Low-Carbohydrate Diets v. Low-Fat Diets on Body Weight and Cardiovascular Risk Factors: A Meta-Analysis of Randomised Controlled Trials

Nadia Mansoor, Kathrine J Vinknes, Marit B Veierød, Kjetil Retterstø
British Journal of Nutrition
2016
Metabolic Syndrome

The effects of low carbohydrate diets on liver function tests in nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials

Fahimeh Haghighatdoost, Amin Salehi-Abargouei, Pamela J. Surkan and Leila Azadbakht
Journal of Research in Medical Science
2016
Metabolic Syndrome

Effect of low-fat diet interventions versus other diet interventions on long-term weight change in adults: a systematic review and meta-analysis

Dr Deirdre K Tobias, ScD Mu Chen, ScD Prof JoAnn E Manson, MD Prof David S Ludwig, MD Prof Walter Willett, MD Prof Frank B Hu, MD
The Lancet Diabetes and Endocrinology
2015
Metabolic Syndrome

Dietary Intervention for Overweight and Obese Adults: Comparison of Low-Carbohydrate and Low-Fat Diets. A Meta-Analysis

Jonathan Sackner-Bernstein , David Kanter and Sanjay Kaul
PLoS One
2015
Diabetes

Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base

Richard D. Feinman, Wendy K. Pogozelski, Arne Astrup, Richard K. Bernstein, Eugene J. Fine, Eric C. Westman, Anthony Accurso, Lynda Frassetto, Barbara A. Gower, Samy I. McFarlane, Jörgen Vesti Nielsen, Thure Krarup, Laura Saslow, Karl S. Roth, Mary C. Vernon, Jeff S. Volek...,Jay Wortman, Nicolai Worm
Nutrition
2015
Diabetes

Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings

Adrienne R. Barnosky Kristin K. Hoddy Terry G. Unterman Krista A. Varady
The Journal of Laboratory and Clinical Medicine
2014
PCOS

Focus on Metabolic and Nutritional Correlates of Polycystic Ovary Syndrome and Update on Nutritional Management of These Critical Phenomena

Mariangela Rondanelli , Simone Perna, Milena Faliva, Francesca Monteferrario, Erica Repaci, Francesca Allieri
Archives of Gynecology and Obstetrics
2014
PCOS

Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth

Joselyn Rojas , Mervin Chávez, Luis Olivar, Milagros Rojas, Jessenia Morillo, José Mejías, María Calvo, and Valmore Bermúdez
International Journal of Reproductive Health
2014
Diabetes

Randomization to a low-carbohydrate diet advice improves health related quality of life compared with a low-fat diet at similar weight-loss in Type 2 diabetes mellitus

H. Guldbrand, T. Lindström, B. Dizdara, B. Bunjaku, C. J. Östgren, F. H. Nystrom, M. Bachrach-Lindström
Diabetes Research and Clinical Practice
2014
Metabolic Syndrome

Gut Bacteria in Health and Disease

Eamonn M. M. Quigley
Gastroenterology and Hepatology
2013
PCOS

Favourable metabolic effects of a eucaloric lower‐carbohydrate diet in women with PCOS

Barbara A. Gower Paula C. Chandler‐Laney Fernando Ovalle Laura Lee Goree Ricardo Azziz Renee A. Desmond Wesley M. Granger Amy M. Goss G.Wright Bates
Clinical Endocrinology
2013
PCOS

Insulin resistance, obesity, inflammation, and depression in polycystic ovary syndrome: biobehavioral mechanisms and interventions

Kristen Farrell, M.S. and Michael H. Antoni, Ph.D
American Society for Reproductive Medicine
2010
Metabolic Syndrome

A Very Low-carbohydrate Diet Improves Symptoms and Quality of Life in Diarrhea-Predominant Irritable Bowel Syndrome

Gregory L. Austin Christine B. Dalton Yuming Hu Carolyn B. Morris Jane Hankins Stephan R. Weinland Eric C. Westman William S. Yancy Jr Douglas A. Drossman
Clinical Gastroenterology and Hepatology
2009
Diabetes

The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus

Eric C Westman, William S Yancy, John C Mavropoulos, Megan Marquart, and Jennifer R McDuffie
Nutrition & Metabolism
2008
Metabolic Syndrome

A Very Low-Carbohydrate Diet Improves Gastroesophageal Reflux and Its Symptoms

Gregory L. Austin, Michelle T. Thiny, Eric C. Westman, William S. Yancy Jr. & Nicholas J. Shaheen
Digestive Diseases and Sciences
2006
PCOS

The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: A pilot study

John C Mavropoulos, William S Yancy, Juanita Hepburn & Eric C Westman
Nutrition & Metabolism
2005
Diabetes

A low-carbohydrate, ketogenic diet to treat type 2 diabetes

William S Yancy Jr, Marjorie Foy, Allison M Chalecki, Mary C Vernon & Eric C Westman
Nutrition & Metabolism
2005
Metabolic Syndrome

A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia

William S. Yancy Jr., MD, MHS, Maren K. Olsen, PhD, John R. Guyton, MD, Ronna P. Bakst, RD, Eric C. Westman, MD, MHS
Annals of Internal Medicine
2004
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